Endonuclease-independent insertion provides an alternative pathway for L1 retrotransposition in the human genome

@inproceedings{Sen2007EndonucleaseindependentIP,
  title={Endonuclease-independent insertion provides an alternative pathway for L1 retrotransposition in the human genome},
  author={Shurjo K Sen and Charles T. L. Huang and Kyudong Han and Mark A. Batzer},
  booktitle={Nucleic acids research},
  year={2007}
}
LINE-1 elements (L1s) are a family of highly successful retrotransposons comprising approximately 17% of the human genome, the majority of which have inserted through an endonuclease-dependent mechanism termed target-primed reverse transcription. Recent in vitro analyses suggest that in the absence of non-homologous end joining proteins, L1 elements may utilize an alternative, endonuclease-independent pathway for insertion. However, it remains unknown whether this pathway operates in vivo or in… CONTINUE READING
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