Endonuclease activities, chromatin structure, and DNA degradation in apoptosis.

@article{Walker1994EndonucleaseAC,
  title={Endonuclease activities, chromatin structure, and DNA degradation in apoptosis.},
  author={Peter F R Walker and Marianna Sikorska},
  journal={Biochemistry and cell biology = Biochimie et biologie cellulaire},
  year={1994},
  volume={72 11-12},
  pages={615-23}
}
The degradation of DNA into a specific pattern of fragments is a characteristic feature of apoptosis. Initially, these fragments were visualized by conventional agarose gel electrophoresis as a DNA ladder consisting of multimers of approximately 200 base pairs. Subsequent analysis by pulsed-field gel electrophoresis showed that there were also fragments in… CONTINUE READING