Endonuclease V of Escherichia coli prevents mutations from nitrosative deamination during nitrate/nitrite respiration.

@article{Weiss2001EndonucleaseVO,
  title={Endonuclease V of Escherichia coli prevents mutations from nitrosative deamination during nitrate/nitrite respiration.},
  author={Bernard Weiss},
  journal={Mutation research},
  year={2001},
  volume={461 4},
  pages={301-9}
}
Endonuclease V (Endo V) of Escherichia coli participates in the excision repair of hypoxanthine and xanthine (deaminated adenine and guanine) in DNA. It thereby reduces the mutagenic effects of nitrous acid by attacking lesions caused by nitrosative deamination. Nitrosating agents may be produced endogenously when E. coli is grown in oxygen-poor cultures, during which nitrate and nitrite replace oxygen as preferred electron acceptors. In this study, the protective effect of Endo V was observed… CONTINUE READING
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