Endonuclease G, a candidate human enzyme for the initiation of genomic inversion in herpes simplex type 1 virus.

@article{Huang2002EndonucleaseGA,
  title={Endonuclease G, a candidate human enzyme for the initiation of genomic inversion in herpes simplex type 1 virus.},
  author={Ke-Jung Huang and Boris V. Zemelman and I Robert Lehman},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 23},
  pages={21071-9}
}
The herpes simplex virus type 1 (HSV-1) a sequence is present as a direct repeat at the two termini of the 152-kilobase viral genome and as an inverted repeat at the junction of the two unique components L and S. During replication, the HSV-1 genome undergoes inversion of L and S, producing an equimolar mixture of the four possible isomers. Isomerization is believed to result from recombination triggered by breakage at the a sequence, a recombinational hot spot. We have identified an enzyme in… CONTINUE READING