Endonuclease (R) subunits of type-I and type-III restriction-modification enzymes contain a helicase-like domain.

@article{Gorbalenya1991EndonucleaseS,
  title={Endonuclease (R) subunits of type-I and type-III restriction-modification enzymes contain a helicase-like domain.},
  author={Alexander E. Gorbalenya and Eugene V. Koonin},
  journal={FEBS letters},
  year={1991},
  volume={291 2},
  pages={277-81}
}
A statistically significant amino acid sequence similarity is demonstrated between the endonuclease (R) subunit of EcoK restriction-modification (R-M) enzyme, and RNA and DNA helicases of the so-called 'DEAD' family. It is further shown that all three known sequences of R subunits of type-I and type-III R-M enzymes contain the conserved amino acid sequence motifs typical of the previously described helicase superfamily II [(1989) Nucleic Acids Res. 17, 4713-4730]. A hypothesis is proposed that… CONTINUE READING

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