Endomysial fibrosis in Duchenne muscular dystrophy: a marker of poor outcome associated with macrophage alternative activation.

@article{Desguerre2009EndomysialFI,
  title={Endomysial fibrosis in Duchenne muscular dystrophy: a marker of poor outcome associated with macrophage alternative activation.},
  author={Isabelle Desguerre and Michelle L. Mayer and France Leturcq and J Barbet and Romain Kroum Gherardi and Christo Christov},
  journal={Journal of neuropathology and experimental neurology},
  year={2009},
  volume={68 7},
  pages={762-73}
}
There is considerable interindividual variability in motor function among patients with Duchenne muscular dystrophy (DMD); moreover, pathogenetic mechanisms of motor dysfunction in DMD are not understood. Using multiparametric analysis, we correlated initial histologic alterations in quadriceps muscle biopsies from 25 steroid therapy-free patients with DMD with 13 relevant clinical features assessed by a single clinical team during a long-term period (mean, >10 years). There was no residual… CONTINUE READING

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