Endomorphins: localization, release and action on rat dorsal horn neurons.

  title={Endomorphins: localization, release and action on rat dorsal horn neurons.},
  author={Nae J. Dun and Siok Le Dun and Sh. Ying Wu and Carole Ann Williams and Ernest H. Kwok},
  journal={Journal of biomedical science},
  volume={7 3},
Endomorphin (Endo) 1 and 2, two tetrapeptides isolated from the bovine and human brain, have been proposed to be the endogenous ligand for the mu-opiate receptor. A multi-disciplinary study was undertaken to address the issues of localization, release and biological action of Endo with respect to the rat dorsal horn. First, immunohistochemical studies showed that Endo-1- or Endo-2-like immunoreactivity (Endo-1- or Endo-2-LI) is selectively expressed in fiber-like elements occupying the… CONTINUE READING


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