Endometrial stromal fibroblasts from women with polycystic ovary syndrome have impaired progesterone-mediated decidualization, aberrant cytokine profiles and promote enhanced immune cell migration in vitro.

@article{Piltonen2015EndometrialSF,
  title={Endometrial stromal fibroblasts from women with polycystic ovary syndrome have impaired progesterone-mediated decidualization, aberrant cytokine profiles and promote enhanced immune cell migration in vitro.},
  author={Terhi T. Piltonen and Joseph C. T. Chen and Masuma Khatun and Marika Kangasniemi and Annikki K Liakka and Trimble L B Spitzer and Nam D. Tran and H. Huddleston and Juan C. Irwin and Linda C. Giudice},
  journal={Human reproduction},
  year={2015},
  volume={30 5},
  pages={1203-15}
}
STUDY QUESTION Do endometrial stromal fibroblasts (eSF) in women with polycystic ovary syndrome (PCOS) (eSFpcos) exhibit altered estrogen and/or progesterone (P4) responses, which may explain some of the adverse reproductive outcomes and endometrial pathologies in these women? SUMMARY ANSWER In vitro, eSF from women with PCOS exhibit an aberrant decidualization response and concomitant changes in pro-inflammatory cytokine, chemokine and matrix metalloproteinase (MMP) release and immune cell… CONTINUE READING