Endometrial glands are required for preimplantation conceptus elongation and survival.

  title={Endometrial glands are required for preimplantation conceptus elongation and survival.},
  author={Christopher A Gray and Kathryn M Taylor and W. Scott Ramsey and Jonathan R. Hill and Fuller W Bazer and Frank F. Bartol and Thomas E Spencer},
  journal={Biology of reproduction},
  volume={64 6},
Endometrial glands secrete molecules hypothesized to support conceptus growth and development. In sheep, endometrial gland morphogenesis occurs postnatally and can be epigenetically ablated by neonatal progestin exposure. The resulting stable adult uterine gland knockout (UGKO) phenotype was used here to test the hypothesis that endometrial glands are required for successful pregnancy. Mature UGKO ewes were bred repeatedly to fertile rams, but no pregnancies were detected by ultrasound on Day… CONTINUE READING


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The ovine uterine gland knockout model: effects of gland ablation on the estrous cycle

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Highly Influential
5 Excerpts

Discovery and characterization of genes expressed in the endometrial epithelium using the ovine uterine gland knockout model

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