Endometrial carcinoma: molecular alterations involved in tumor development and progression

  title={Endometrial carcinoma: molecular alterations involved in tumor development and progression},
  author={Andr{\'e}e Yeramian and Gema Moreno-Bueno and Xavier Dolcet and Llu{\'i}s Catas{\'u}s and Miguel Abal and Eva Colas and Jaume Revent{\'o}s and Jos{\'e} Palacios and Jaime Prat and Xavier Mat{\'i}as-Guiu},
In the western world, endometrial carcinoma (EC) is the most common cancer of the female genital tract. The annual incidence has been estimated at 10–20 per 100 000 women. Two clinicopathological variants are recognized: the estrogen related (type I, endometrioid) and the non-estrogen related (type II, non-endometrioid).The clinicopathological differences are paralleled by specific genetic alterations, with type I showing microsatellite instability and mutations in phosphatase and tensin… CONTINUE READING
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