Endometrial cancer and Lynch syndrome: clinical and pathologic considerations.

  title={Endometrial cancer and Lynch syndrome: clinical and pathologic considerations.},
  author={Larissa A. Meyer and Russell R. Broaddus and Karen H. Lu},
  journal={Cancer control : journal of the Moffitt Cancer Center},
  volume={16 1},
BACKGROUND Approximately 2% to 5% of endometrial cancers may be due to an inherited susceptibility. Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC) syndrome, an autosomal-dominant inherited cancer susceptibility syndrome caused by a germline mutation in one of the DNA mismatch repair genes, accounts for the majority of inherited cases. Lynch syndrome is associated with early onset of cancer and the development of multiple cancer types, particularly colon and… CONTINUE READING
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