Endometrial apoptosis in patients with dysfunctional uterine bleeding

  title={Endometrial apoptosis in patients with dysfunctional uterine bleeding},
  author={Stewart and Campbell‐Brown and Critchley and Farquharson},
To assess glandular apoptosis in the zona functionalis of proliferative phase endometrium in normal individuals and in patients with dysfunctional uterine bleeding (DUB). 
Structural changes in endometrial basal glands during menstruation
Structural changes in endometrial basal glands during menstruation are described in Garry R, Hart R, Karthigasu KA, Burke C.
The differential expression of oestrogen receptors, progesterone receptors, Bcl‐2 and Ki67 in endometrial polyps
Objective To obtain a greater understanding of the pathogenesis of endometrial polyps and to gain insight into which factors play a pivotal role in their growth.
Dysfunctional Uterine Bleeding
This chapter specifically addresses uterine bleeding due to alterations in the normal cyclical hormonal stimulation of the endometrium, commonly referred to as dysfunctional uterine bleed (DUB).
Apoptosis in endometria of dysfuntional uterine bleeding women.
An insight is given to the existence of a correlative pattern of apoptosis in DUB cases and an increased apoptotic index correlating with high Bcl-2 expression, reflecting the actual cell burden, is observed.
Apoptosis in the endometrium
Consideration will be given here to some of the factors that influence endometrial apoptosis, the most important clinically is the spectrum of premalignant and malignant neoplasms of the endometrium, in which deregulation of apoptosis has been observed.
Progesterone ameliorates the endometrial polyp by modulating the signaling pathway of Wnt and β‐catenin via regulating the expression of H19 and miR‐152
This study aimed to explore the potential mechanism of the involvement of H19 and miR‐152 in an endometrial polyp and to investigate the role of microRNAs in the pathogenesis of various diseases.
Apoptosis of endometrial cells in the bitch.
Results indicate that degeneration of cells of the glandular epithelium, but not of the luminal epithelia, was due to apoptosis of these cells.
Human uterine vascular structures in normal and diseased states
The normal anatomy and physiology of uterine vascular growth, breakdown, and repair is discussed and where altered anatomy and function may contribute to menstrual disorder is indicated.
Apoptotic Cell Death in Ewe Endometrium during the Oestrous Cycle
It is concluded that apoptosis and proliferation were occurred in ewe endometrium in a cyclic pattern and under the influence of the endocrine profile.
Clinical implications of disturbances of uterine vascular morphology and function.
  • M. Hickey, I. Fraser
  • Medicine
    Bailliere's best practice & research. Clinical obstetrics & gynaecology
  • 2000
Improved understanding of the regulation of the uterine vasculature is likely to lead to targeted therapies to prevent unscheduled vascular breakdown and to control menstrual disturbance at an endometrial level.


Endometrial sex steroid receptor expression in women with menorrhagia
Objective To investigate the oestrogen and progesterone receptor distribution in endometrium from reproductive age and perimenopausal women with and without menorrhagia.
Interpretation of endometrial biopsies and curettings
A system for collecting data and assessing the functional state of the endometrium is included, along with discussions on infertility, endometritis, hyperplasia and adenocarcinoma.
Atrophy and apoptosis in the cyclical human endometrium
Electron microscopy of human cyclical endometrium indicates that there is considerable loss of gland epithelial cells with formation of apoptotic bodies in the late secretory, premenstrual and
Dysfunctional uterine bleeding.
  • R. Casper
  • Medicine
    Canadian family physician Medecin de famille canadien
  • 1983
Dysfunctional uterine bleeding is most commonly associated with chronic anovulation and Hysterectomy is probably the treatment of choice for women who have finished their childbearing career and in whom persisting menorrhagia during ovulatory cycles results in anemia.
Histology of the Human Endometrium: From Birth to Senescence
The intimate inter-relationship between endometrial structure/function and steroid hormones during the premenopausal period serves as an indicator of the hypothalamo-pituitary-ovarian axis as related to ovulatory states.
Signals and molecular pathways involved in apoptosis, with special emphasis on human endometrium.
The purpose of this review is to highlight some of the signals and molecular events which are associated with and that may participate in apoptosis, and a review of the current literature regarding apoptosis in human endometrium.
The endometrial deficient secretory phase
It is apparent from this study that the endometrial appearances described represent a definable condition that may be linked to menstrual irregularities and, in some circumstances, infertility; it should be more widely recognized.
Detection of apoptosis in human endometriotic tissues.
The results suggest that the features of ovarian endometriosis are different from those of adenomyosis and eutopic endometrium in terms of the involvement of apoptosis, and the regulatory mechanism involved in ovarian endometricriosis may differ from that in other endometrial cells.
Importance of apoptosis in the histopathology of drug related lesions in the large intestine.
  • F. Lee
  • Medicine, Biology
    Journal of clinical pathology
  • 1993
The presence of crypt apoptoses in substantial numbers (with an apoptotic count in excess of 5) should always raise the possibility of drug effect, especially with NSAIDs, which might well be immunologically mediated.
The signals and molecular pathways involved in implantation, a symbiotic interaction between blastocyst and endometrium involving adhesion and tissue invasion.
The cellular and molecular interactions that take place during implantation are discussed and many signals and molecular pathways are recognized that induce, or regulate the complex series of interactions required for implantation.