Endometrial TIMP-4 mRNA is high at midcycle and in hyperplasia, but down-regulated in malignant tumours. Coordinated expression with MMP-26.

@article{Pilka2004EndometrialTM,
  title={Endometrial TIMP-4 mRNA is high at midcycle and in hyperplasia, but down-regulated in malignant tumours. Coordinated expression with MMP-26.},
  author={Radovan Pilka and Henryk A. Domanski and Stefan Rocco Hansson and Per Eriksson and Bertil Cassl{\'e}n},
  journal={Molecular human reproduction},
  year={2004},
  volume={10 9},
  pages={641-50}
}
We have previously reported that endometrial expression of matrix metalloproteinase (MMP)-26 mRNA comes to a maximum in the early secretory phase. Since tissue inhibitor of metalloproteinase (TIMP)-4 is a potent inhibitor of MMP-26, the objective of this study was to identify the pattern of TIMP-4 mRNA expression in the normal endometrial cycle. We also evaluated hyperplastic, pre-malignant (atypical hyperplasia) and malignant endometrial tissue. Endometrial TIMP-4 mRNA was localized in tissue… CONTINUE READING

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