Endolysosomal proteases and their inhibitors in immunity

  title={Endolysosomal proteases and their inhibitors in immunity},
  author={Phillip I Bird and Joseph A. Trapani and Jose A Villadangos},
  journal={Nature Reviews Immunology},
The cellular endolysosomal compartment is dynamic, complex and incompletely understood. Its organelles and constituents vary between different cell types, but endolysosomal proteases are key components of this compartment in all cells. In immune cells, these proteases function in pathogen recognition and elimination, signal processing and cell homeostasis, and they are regulated by dedicated inhibitors. Pathogens can produce analogous proteases to subvert the host immune response. The balance… CONTINUE READING

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