Endolysosomal processing of exogenous antigen into major histocompatibility complex class I-binding peptides.

@article{Chen2004EndolysosomalPO,
  title={Endolysosomal processing of exogenous antigen into major histocompatibility complex class I-binding peptides.},
  author={Liying M. Chen and Mikael Jondal},
  journal={Scandinavian journal of immunology},
  year={2004},
  volume={59 6},
  pages={545-52}
}
An alternative endolysosomal pathway has recently been suggested for the processing of MHC-I-binding peptides, and peptide/MHC-I complexes have been demonstrated in this compartment. However, it remains unclear where in the antigen-presenting cells such peptides are processed, in the endolysosomes themselves or in the proteasomal complex. Here, we have investigated this using monoclonal antibodies specific for the immunodominant SIINFEKL/Kb complex (25-D1) or for the carbohydrate part of Db- or… CONTINUE READING

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