Endolysosomal membrane trafficking complexes drive nutrient-dependent TORC1 signaling to control cell growth in Saccharomyces cerevisiae.

@article{Kingsbury2014EndolysosomalMT,
  title={Endolysosomal membrane trafficking complexes drive nutrient-dependent TORC1 signaling to control cell growth in Saccharomyces cerevisiae.},
  author={Joanne M. Kingsbury and Neelam Dabas Sen and Tatsuya Maeda and Joseph Heitman and Maria Elena Cardenas},
  journal={Genetics},
  year={2014},
  volume={196 4},
  pages={1077-89}
}
The rapamycin-sensitive and endomembrane-associated TORC1 pathway controls cell growth in response to nutrients in eukaryotes. Mutations in class C Vps (Vps-C) complexes are synthetically lethal with tor1 mutations and confer rapamycin hypersensitivity in Saccharomyces cerevisiae, suggesting a role for these complexes in TORC1 signaling. Vps-C complexes are required for vesicular trafficking and fusion and comprise four distinct complexes: HOPS and CORVET and their minor intermediaries (i… CONTINUE READING
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