Endolides A and B, Vasopressin and Serotonin-Receptor Interacting N-Methylated Peptides from the Sponge-Derived Fungus Stachylidium sp.

@article{Almeida2016EndolidesAA,
  title={Endolides A and B, Vasopressin and Serotonin-Receptor Interacting N-Methylated Peptides from the Sponge-Derived Fungus Stachylidium sp.},
  author={C. Almeida and Fayrouz El Maddah and S. Kehraus and G. Schnakenburg and G. K{\"o}nig},
  journal={Organic letters},
  year={2016},
  volume={18 3},
  pages={
          528-31
        }
}
  • C. Almeida, Fayrouz El Maddah, +2 authors G. König
  • Published 2016
  • Chemistry, Medicine
  • Organic letters
  • The marine-derived fungus Stachylidium sp. was isolated from the sponge Callyspongia sp. cf. C. flammea. Culture on a biomalt medium supplemented with sea salt led to the isolation of two new, most unusual N-methylated peptides, i.e., the tetrapeptides endolide A and B (1 and 2). Both of these contain the very rare amino acid 3-(3-furyl)-alanine. In radioligand binding assays endolide A (1) showed affinity to the vasopressin receptor 1A with a Ki of 7.04 μM, whereas endolide B (2) exhibited no… CONTINUE READING
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