Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration.


Endoglin, a transmembrane glycoprotein that acts as a transforming growth factor-beta (TGF-beta) coreceptor, is downregulated in PC3-M metastatic prostate cancer cells. When restored, endoglin expression in PC3-M cells inhibits cell migration in vitro and attenuates the tumorigenicity of PC3-M cells in SCID mice, though the mechanism of endoglin regulation… (More)
DOI: 10.1093/carcin/bgp217

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