Endoglin controls cell migration and composition of focal adhesions: function of the cytosolic domain.

@article{Conley2004EndoglinCC,
  title={Endoglin controls cell migration and composition of focal adhesions: function of the cytosolic domain.},
  author={Barbara A. Conley and Rositsa I Koleva and Joshua D. Smith and Doreen Kacer and Dongwang Zhang and Carmelo Bernabeu and Calvin P. H. Vary},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 26},
  pages={27440-9}
}
Mutations in the human endoglin gene result in hereditary hemorrhagic telangiectasia type 1, a vascular disorder characterized by multisystemic vascular dysplasia, arteriovenous malformations, and focal dilatation of postcapillary venules. Previous studies have implicated endoglin in the inhibition of cell migration in vivo and in vitro. In the course of studies to address the relationship of the conserved cytosolic domain to endoglin function, we identified zyxin, a LIM domain protein that is… CONTINUE READING

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