Endoglin and activin receptor-like kinase 1 heterozygous mice have a distinct pulmonary and hepatic angiogenic profile and response to anti-VEGF treatment

@article{Ardelean2013EndoglinAA,
  title={Endoglin and activin receptor-like kinase 1 heterozygous mice have a distinct pulmonary and hepatic angiogenic profile and response to anti-VEGF treatment},
  author={Daniela Simona Ardelean and Mirjana Jerkic and Melissa Yin and Madonna R Peter and Bo Yee Ngan and Robert S. Kerbel and F. Stuart Foster and Michelle Letarte},
  journal={Angiogenesis},
  year={2013},
  volume={17},
  pages={129-146}
}
Hereditary hemorrhagic telangiectasia (HHT) is a vascular dysplasia associated with dysregulated angiogenesis and arteriovascular malformations. The disease is caused by mutations in endoglin (ENG; HHT1) or activin receptor-like kinase 1 (ALK1; HHT2) genes, coding for transforming growth factor β (TGF-β) superfamily receptors. Vascular endothelial growth… CONTINUE READING