Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development.

@article{Arthur2000EndoglinAA,
  title={Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development.},
  author={Helen M Arthur and Janice Ure and Allanceson J. Smith and Glenn L. Renforth and David I. Wilson and Evelyn Torsney and Richard Charlton and Dinah V Parums and T. Jowett and Douglas A. Marchuk and John Burn and Austin G. Diamond},
  journal={Developmental biology},
  year={2000},
  volume={217 1},
  pages={42-53}
}
Endoglin (CD105) is expressed on the surface of endothelial and haematopoietic cells in mammals and binds TGFbeta isoforms 1 and 3 in combination with the signaling complex of TGFbeta receptors types I and II. Endoglin expression increases during angiogenesis, wound healing, and inflammation, all of which are associated with TGFbeta signaling and alterations in vascular structure. The importance of endoglin for normal vascular architecture is further indicated by the association of mutations in… CONTINUE READING
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