Endogenously synthesized peptide with an endoplasmic reticulum signal sequence sensitizes antigen processing mutant cells to class I- restricted cell-mediated lysis

@article{Anderson1991EndogenouslySP,
  title={Endogenously synthesized peptide with an endoplasmic reticulum signal sequence sensitizes antigen processing mutant cells to class I- restricted cell-mediated lysis},
  author={Kristin A. Anderson and Peter Cresswell and Maureen C. Gammon and Jeff Hermes and A. -L. Williamson and Hans J. Zweerink},
  journal={The Journal of Experimental Medicine},
  year={1991},
  volume={174},
  pages={489 - 492}
}
The HLA-A2-positive human mutant cell line T2 is not lysed by influenza virus-specific HLA-A2-restricted cytotoxic lymphocytes after virus infection. However, lysis does occur when cells are incubated with the antigenic influenza matrix protein-derived peptide M57-68. To examine the nature of this defect, T2 cells were transfected with two different plasmids. One plasmid encoded the peptide M57-68, and the other encoded the same peptide preceded by an endoplasmic reticulum translocation signal… CONTINUE READING

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