Endogenously produced IL-12 is required for the induction of protective T cells during Mycobacterium avium infections in mice.

@article{Castro1995EndogenouslyPI,
  title={Endogenously produced IL-12 is required for the induction of protective T cells during Mycobacterium avium infections in mice.},
  author={A. G. G{\'o}mez Castro and Regina A. Silva and Rui Appelberg},
  journal={Journal of immunology},
  year={1995},
  volume={155 4},
  pages={2013-9}
}
Immunity to Mycobacterium avium depends on the induction of protective CD4+ T cells. In mice, M. avium induces a Th1 response leading to protective immunity dependent on IFN-gamma and TNF. In this study, we analyzed whether endogenously produced IL-12 was involved in the generation of such protective T cells. We found that the neutralization of IL-12 with… CONTINUE READING