Endogenously expressed Trp1 is involved in store-mediated Ca2+ entry by conformational coupling in human platelets.

@article{Rosado2002EndogenouslyET,
  title={Endogenously expressed Trp1 is involved in store-mediated Ca2+ entry by conformational coupling in human platelets.},
  author={Juan Antonio Rosado and Sharon L Brownlow and Stewart O. Sage},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 44},
  pages={
          42157-63
        }
}
Physical interaction between transient receptor potential (Trp) channels and inositol 1,4,5-trisphosphate receptors (IP(3)Rs) has been presented as a candidate mechanism for the activation of store-mediated Ca(2+) entry. The role of a human homologue of Drosophila transient receptor potential channel, hTrp1, in the conduction of store-mediated Ca(2+) entry was examined in human platelets. Incubation of platelets with a specific antibody, which recognizes the extracellular amino acid sequence… CONTINUE READING
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