Endogenously expressed IL-13Rα2 attenuates IL-13-mediated responses but does not activate signaling in human lung fibroblasts.

@article{Chandriani2014EndogenouslyEI,
  title={Endogenously expressed IL-13Rα2 attenuates IL-13-mediated responses but does not activate signaling in human lung fibroblasts.},
  author={Sanjay J. Chandriani and Daryle J DePianto and Elsa N. N'Diaye and Alexander R Abbas and Janet Jackman and Jack J. Bevers and Vladimir Ramirez-Carrozzi and Rajita Pappu and Steven E Kauder and Karen Toy and Connie Ha and Zora Modrusan and Lawren C. Wu and Harold R. Collard and Paul J Wolters and Jackson G. Egen and Joseph R. Arron},
  journal={Journal of immunology},
  year={2014},
  volume={193 1},
  pages={111-9}
}
IL-13 can bind to two distinct receptors: a heterodimer of IL-13Rα1/IL-4Rα and IL-13Rα2. Whereas IL-13Rα1/IL-4Rα engagement by IL-13 leads to the activation of STAT6, the molecular events triggered by IL-13 binding to IL-13Rα2 remain incompletely understood. IL-4 can bind to and signal through the IL-13Rα1/IL-4Rα complex but does not interact with IL-13Rα2. Idiopathic pulmonary fibrosis is a progressive and generally fatal parenchymal lung disease of unknown etiology with no current… CONTINUE READING