Endogenous versus exogenous thiols in radioprotection.

@article{Vos1988EndogenousVE,
  title={Endogenous versus exogenous thiols in radioprotection.},
  author={O. Vos and W S Roos-Verhey},
  journal={Pharmacology \& therapeutics},
  year={1988},
  volume={39 1-3},
  pages={
          169-77
        }
}

Radiation Oncology: Past Achievements

Major advances in cancer therapy are likely to come with improved combined modality treatment representing inte gration of local modalities with the systemic, according to this opinion.

Glutathione and glutathione delivery compounds.

Effects of cadmium on haemopoiesis in irradiated and non-irradiated mice: 1. Relationship to the number of myeloid progenitor cells.

Pretreatment with cadmium significantly reduced the lethal effects of gamma rays and increased the number of endogenous haemopoietic stem cells (endoCFU-S) in a concentration-dependent manner.

Radioprotective effect of exogenous glutathione on rat parotid glands.

It was shown that elevation of the intraglandular level of NPSH after exogenous administration of GSH protected the parotid glands from radiation injury in the rat.

Thiol uptake by Chinese hamster V79 cells and aerobic radioprotection as a function of the net charge on the thiol.

Thiols studied showed that hydroxyl radical scavenging and DNA radical repair are important mechanisms in the protection of cells by thiols and that the net charge on the thiol is a significant factor in its effectiveness.

Glutathione modulation in cancer treatment: will it work?

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