Endogenous vasopressin contributes to hypothalamic-pituitary-adrenocortical alterations in aged rats.

@article{Hatzinger2000EndogenousVC,
  title={Endogenous vasopressin contributes to hypothalamic-pituitary-adrenocortical alterations in aged rats.},
  author={M Hatzinger and Carsten T. Wotjak and Takako Naruo and R Simchen and Martin E. Keck and Rainer Landgraf and Florian Holsboer and Inga D. Neumann},
  journal={The Journal of endocrinology},
  year={2000},
  volume={164 2},
  pages={197-205}
}
The ageing process in animals and humans is thought to be accompanied by a gradual impairment of corticosteroid receptor function, which is reflected by increased pituitary-adrenocortical hormone secretion at baseline and a number of aberrant neuroendocrine function test results. The latter include the ACTH and corticosteroid responses to a combined dexamethasone (DEX)/corticotropin-releasing hormone (CRH) challenge. The excessive hormonal response to this test among aged individuals has been… CONTINUE READING