Endogenous type II cGMP-dependent protein kinase exists as a dimer in membranes and can Be functionally distinguished from the type I isoforms.

@article{Vaandrager1997EndogenousTI,
  title={Endogenous type II cGMP-dependent protein kinase exists as a dimer in membranes and can Be functionally distinguished from the type I isoforms.},
  author={Arie B. Vaandrager and Marcel Edixhoven and Alice G M Bot and Marian A. Kroos and Thomas Jarchau and Suzanne M. Lohmann and Hans Gottfried Genieser and Hugo R. de Jonge},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 18},
  pages={11816-23}
}
In mammalian tissues two types of cGMP-dependent protein kinase (cGK) have been identified. In contrast to the dimeric cGK I, cGK II purified from pig intestine was shown previously to behave as a monomer. However, recombinant rat cGK II was found to have hydrodynamic parameters indicative of a homodimer. Chemical cross-linking studies showed that pig cGK II in intestinal membranes has a dimeric structure as well. However, after purification, cGK II was found to be partly proteolyzed into C… CONTINUE READING