Endogenous tumour necrosis factor-alpha sensitise melanoma cells to glucosaminylmuramyl dipeptide.

Abstract

Flow cytometry was used to demonstrate that cultured human melanoma BRO cells expressed membrane-bound tumour necrosis factor-alpha (TNF-alpha) and were able to release TNF-alpha upon treatment with glucosaminylmuramyl dipeptide (GMDP). The released TNF-alpha was shown to prime melanoma cells, previously unable to respond to GMDP by increasing expression of melanoma-associated antigens, making them sensitive to GMDP treatment.

Cite this paper

@article{Valyakina1998EndogenousTN, title={Endogenous tumour necrosis factor-alpha sensitise melanoma cells to glucosaminylmuramyl dipeptide.}, author={Tatiana I Valyakina and Ravilya L Komaleva and Elena E Petrova and Andrey Malakhov and Olga G. Shamborant and Tatiana M Andronova and Vladimir Andreevich Nesmeyanov}, journal={FEBS letters}, year={1998}, volume={426 3}, pages={373-6} }