Endogenous tumor necrosis factor functions as a resistant factor against hyperthermic cytotoxicity.

@article{Tsuji1992EndogenousTN,
  title={Endogenous tumor necrosis factor functions as a resistant factor against hyperthermic cytotoxicity.},
  author={Yoshiyuki Tsuji and Norihiko Watanabe and Takashi Okamoto and Naoki Tsuji and Hiroki Sasaki and Shin-ichi Akiyama and Naofurai Yamauchi and Yoshiro Niitsu},
  journal={Cancer research},
  year={1992},
  volume={52 22},
  pages={6258-62}
}
One of the mechanisms of cytotoxicity by tumor necrosis factor (TNF) is the induction of reactive oxygen molecules. Cells producing endogenous tumor necrosis factor (enTNF) show resistance to the cytotoxicity of exogenous TNF by scavenging the reactive oxygen molecules. The intracellular hydroxyl radical production is also known to be involved in the heat-induced cytotoxicity. In the present study, we therefore examined the possibility that enTNF may act as a protective protein against the heat… CONTINUE READING