Endogenous tumor necrosis factor exerts its protective function intracellularly against the cytotoxicity of exogenous tumor necrosis factor.

@article{Okamoto1992EndogenousTN,
  title={Endogenous tumor necrosis factor exerts its protective function intracellularly against the cytotoxicity of exogenous tumor necrosis factor.},
  author={Tomomi Okamoto and Norihiko Watanabe and Naofurai Yamauchi and Youki Tsuji and Naoki Tsuji and Yasushi Itoh and Hiroshi Neda and Yorikazu Niitsu},
  journal={Cancer research},
  year={1992},
  volume={52 19},
  pages={5278-81}
}
Based on the findings that expression of endogenous tumor necrosis factor (enTNF), which is not present in TNF-susceptible cells, was generally observed in TNF-resistant cells and that TNF gene transfection gives rise to TNF resistance, the assumption was made that enTNF may be a protective protein against the cytotoxicity of exogenous TNF. However, it remains unknown whether the protection by enTNF is exerted in an intracellular or extracellular (autocrine) manner. We therefore transfected a… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 30 references

Molecular cloning and expression of a receptor for human tumor necrosis

T. J. Schall, M. Lewis, +10 authors D. V. Goeddel
factor. Cell, • 1990

Molecular cloning and expression of the human 55 kD tumor necrosis factor receptor

H. Loetscher, Pan, +6 authors W. Lesslauer
Cell • 1990
View 1 Excerpt

Similar Papers

Loading similar papers…