Endogenous tumor necrosis factor as a predictor of doxorubicin sensitivity in leukemic patients.

@article{Kobayashi1997EndogenousTN,
  title={Endogenous tumor necrosis factor as a predictor of doxorubicin sensitivity in leukemic patients.},
  author={Daisuke Kobayashi and Norihiko Watanabe and Naofurai Yamauchi and Naoki Tsuji and Tsutomu Sato and Yoshiro Niitsu},
  journal={Blood},
  year={1997},
  volume={89 7},
  pages={2472-9}
}
We have previously reported that intracellular tumor necrosis factor (enTNF) is responsible for resistance, in established cell lines to doxorubicin (DOX), exogenous TNF, and heat stress by inducing manganous superoxide dismutase (MnSOD), thereby scavenging reactive oxygen free radicals. Leukemic cells from 19 patients (6 acute lymphoblastic leukemia, 13… CONTINUE READING