Endogenous truncated TrkB.T1 receptor regulates neuronal complexity and TrkB kinase receptor function in vivo.

@article{CarimTodd2009EndogenousTT,
  title={Endogenous truncated TrkB.T1 receptor regulates neuronal complexity and TrkB kinase receptor function in vivo.},
  author={Laura Carim-Todd and Kevin G. Bath and Gianluca Fulgenzi and Sudhirkumar U. Yanpallewar and Deqiang Q Jing and Colleen A. Barrick and Jodi Becker and Hannah Buckley and Susan G Dorsey and Francis B. S. Lee and Lino Tessarollo},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2009},
  volume={29 3},
  pages={678-85}
}
Pathological or in vitro overexpression of the truncated TrkB (TrkB.T1) receptor inhibits signaling through the full-length TrkB (TrkB.FL) tyrosine kinase receptor. However, to date, the role of endogenous TrkB.T1 is still unknown. By studying mice lacking the truncated TrkB.T1 isoform but retaining normal spatiotemporal expression of TrkB.FL, we have… CONTINUE READING