Endogenous siRNA and miRNA Targets Identified by Sequencing of the Arabidopsis Degradome

@article{AddoQuaye2008EndogenousSA,
  title={Endogenous siRNA and miRNA Targets Identified by Sequencing of the Arabidopsis Degradome},
  author={Charles Addo-Quaye and Tifani W. Eshoo and David P. Bartel and Michael J. Axtell},
  journal={Current Biology},
  year={2008},
  volume={18},
  pages={758-762}
}
MicroRNAs (miRNAs) regulate the expression of target mRNAs in plants and animals [1]. Plant miRNA targets have been predicted on the basis of their extensive and often conserved complementarity to the miRNAs [2-4], as well as on miRNA overexpression experiments [5]; many of these target predictions have been confirmed by isolation of the products of miRNA-directed cleavage. Here, we present a transcriptome-wide experimental method, called "degradome sequencing," to directly detect cleaved miRNA… CONTINUE READING
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