Endogenous serotonin modulates histamine release in the rat hypothalamus as measured by in vivo microdialysis.

Abstract

In vivo microdialysis was used to study the effects of serotonergic drugs on histamine release from the suprachiasmatic nuclei region of the anterior hypothalamus in anesthetized rats. Local perfusion with serotonin (5-hydroxytryptamine, 5-HT) increased histamine release significantly and dose dependently. Methysergide (10 mg/kg i.p.), a 5-HT2C/2A receptor… (More)

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@article{Laitinen1995EndogenousSM, title={Endogenous serotonin modulates histamine release in the rat hypothalamus as measured by in vivo microdialysis.}, author={Kai Laitinen and Leena M Tuomisto and Jukka Laitinen}, journal={European journal of pharmacology}, year={1995}, volume={285 2}, pages={159-64} }