Endogenous secretory receptor for advanced glycation end-products inhibits amyloid-β1-42 uptake into mouse brain.

@article{Sugihara2012EndogenousSR,
  title={Endogenous secretory receptor for advanced glycation end-products inhibits amyloid-β1-42 uptake into mouse brain.},
  author={T. Sugihara and S. Munesue and Y. Yamamoto and S. Sakurai and N. Akhter and Y. Kitamura and K. Shiba and T. Watanabe and H. Yonekura and Y. Hayashi and J. Hamada and H. Yamamoto},
  journal={Journal of Alzheimer's disease : JAD},
  year={2012},
  volume={28 3},
  pages={
          709-20
        }
}
The cell-surface receptor for advanced glycation end-products (RAGE) has been implicated in the development of diabetic vascular complications and Alzheimer's disease. RAGE has been considered to be involved in amyloid-β1-42 (Aβ1-42) uptake into brain. In the present study, we demonstrate that endogenous secretory RAGE (esRAGE), a decoy form of RAGE generated by alternative RNA processing, is able to inhibit Aβ1-42 influx into mouse brain. Surface plasmon resonance and competitive binding… Expand
11 Citations
Neuroprotective Effects of Endogenous Secretory Receptor for Advanced Glycation End-products in Brain Ischemia
  • 5
  • PDF
Role of RAGE in Alzheimer’s Disease
  • 112
Gene doubling increases glyoxalase 1 expression in RAGE knockout mice.
  • 5
In vitro anticancer effects of a RAGE inhibitor discovered using a structure-based drug design system.
  • 10
Value of RAGE as a circulating biomarker : from sRAGE to anti-sRAGE autoantibodies
  • PDF
...
1
2
...

References

SHOWING 1-10 OF 55 REFERENCES
Reduced expression of endogenous secretory receptor for advanced glycation endproducts in hippocampal neurons of Alzheimer's disease brains.
  • 25
The Receptor for Advanced Glycation End Products (RAGE) Is a Cellular Binding Site for Amphoterin
  • 971
  • PDF
Ectodomain shedding of the receptor for advanced glycation end products: a novel therapeutic target for Alzheimer’s disease
  • 37
  • Highly Influential
Expression profiling of endogenous secretory receptor for advanced glycation end products in human organs
  • 137
  • PDF
A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane‐bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10)
  • A. Raucci, Simona Cugusi, +6 authors M. Bianchi
  • Chemistry, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2008
  • 443
  • Highly Influential
Purification and Characterization of Mouse Soluble Receptor for Advanced Glycation End Products (sRAGE)*
  • 204
  • Highly Influential
  • PDF
Receptor for Advanced Glycation End Products Is Subjected to Protein Ectodomain Shedding by Metalloproteinases*
  • 230
  • Highly Influential
  • PDF
RAGE regulates BACE1 and Aβ generation via NFAT1 activation in Alzheimer's disease animal model
  • H. Cho, S. Son, +5 authors I. Mook-Jung
  • Medicine, Biology
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2009
  • 103
...
1
2
3
4
5
...