Endogenous rhythm generation in the pre-Bötzinger complex and ionic currents: modelling and in vitro studies.

  title={Endogenous rhythm generation in the pre-B{\"o}tzinger complex and ionic currents: modelling and in vitro studies.},
  author={Ilya A. Rybak and Natalia A. Shevtsova and Walter M St-John and Julian Paton and Olivier Pierrefiche},
  journal={The European journal of neuroscience},
  volume={18 2},
The pre-Bötzinger complex is a small region in the mammalian brainstem involved in generation of the respiratory rhythm. As shown in vitro, this region, under certain conditions, can generate endogenous rhythmic bursting activity. Our investigation focused on the conditions that may induce this bursting behaviour. A computational model of a population of pacemaker neurons in the pre-Bötzinger complex was developed and analysed. Each neuron was modelled in the Hodgkin-Huxley style and included… CONTINUE READING