Endogenous reverse transcription of human immunodeficiency virus type 1 in physiological microenviroments: an important stage for viral infection of nondividing cells.

@article{Zhang1996EndogenousRT,
  title={Endogenous reverse transcription of human immunodeficiency virus type 1 in physiological microenviroments: an important stage for viral infection of nondividing cells.},
  author={Hui Zhang and Geethanjali Dornadula and Roger J. Pomerantz},
  journal={Journal of virology},
  year={1996},
  volume={70 5},
  pages={2809-24}
}
Endogenous reverse transcription (ERT) of retroviruses has long been considered a somewhat artificial process which only mimics reverse transcription occurring in target cells, as detergents or amphipathic peptides have classically been used to make the envelopes of retroviruses in these reaction systems permeable. Recently, several studies suggested that ERT of human immunodeficiency virus type 1 (HIV-1) might occur without detergent treatment. However, this phenomenon could be due to damage… CONTINUE READING
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DNA found in HIV-1 particles may not be required for infectivity

  • E. J. Arts, J. Mak, L. Kleinman, M. A. Wainberg
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