Endogenous reverse transcriptase: a mediator of cell proliferation and differentiation.

@article{Spadafora2004EndogenousRT,
  title={Endogenous reverse transcriptase: a mediator of cell proliferation and differentiation.},
  author={Corrado Spadafora},
  journal={Cytogenetic and genome research},
  year={2004},
  volume={105 2-4},
  pages={346-50}
}
Endogenous, non-telomeric Reverse Transcriptase (RT) is encoded by two classes of repeated genomic elements, retrotransposons and endogenous retroviruses, and is an essential component of the retrotransposition machinery of both types of elements. Expression of RT-coding genes is generally repressed in non-pathological, terminally differentiated cells, but is active in early embryos, germ cells, embryo and tumor tissues, all of which have a high proliferative potential. To clarify whether… CONTINUE READING

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