Endogenous retroviruses regulate periimplantation placental growth and differentiation.

  title={Endogenous retroviruses regulate periimplantation placental growth and differentiation.},
  author={Kathrin A. Dunlap and Massimo Palmarini and Mariana Varela and Robert C. Burghardt and Kanako Hayashi and Jennifer L Farmer and Thomas E Spencer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 39},
Endogenous retroviruses (ERVs) are fixed and abundant in the genomes of vertebrates. Circumstantial evidence suggests that ERVs play a role in mammalian reproduction, particularly placental morphogenesis, because intact ERV envelope genes were found to be expressed in the syncytiotrophoblasts of human and mouse placenta and to elicit fusion of cells in vitro. We report here in vivo and in vitro experiments finding that the envelope of a particular class of ERVs of sheep, endogenous Jaagsiekte… CONTINUE READING
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Placenta 27(Suppl A):5135–5140

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