Endogenous retroviruses provide the primary polyadenylation signal for two new human genes (HHLA2 and HHLA3).

@article{Mager1999EndogenousRP,
  title={Endogenous retroviruses provide the primary polyadenylation signal for two new human genes (HHLA2 and HHLA3).},
  author={Dixie L. Mager and D. G. N. Hunter and Michael Schertzer and J. Douglas Freeman},
  journal={Genomics},
  year={1999},
  volume={59 3},
  pages={255-63}
}
By screening the expressed sequence tag (EST) database, we identified transcripts of two new human genes that are polyadenylated within a long terminal repeat (LTR) of the HERV-H endogenous retrovirus family. The first gene, termed HHLA2, is represented by two EST clones and one cDNA clone, all of which have a polyadenylated LTR as their 3' end. The gene has an open reading frame (ORF) of 414 amino acids with three immunoglobulin-like domains and is expressed primarily in intestinal tissues… CONTINUE READING

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