Endogenous retroviral LTRs as promoters for human genes: a critical assessment.

@article{Cohen2009EndogenousRL,
  title={Endogenous retroviral LTRs as promoters for human genes: a critical assessment.},
  author={Carla Jayne Cohen and Wynne M Lock and Dixie L. Mager},
  journal={Gene},
  year={2009},
  volume={448 2},
  pages={105-14}
}
Gene regulatory changes are thought to be major factors driving species evolution, with creation of new regulatory regions likely being instrumental in contributing to diversity among vertebrates. There is growing appreciation for the role of transposable elements (TEs) in gene regulation and, indeed, laboratory investigations have confirmed many specific examples of mammalian genes regulated by promoters donated by endogenous retroviruses (ERVs) or other TEs. Bioinformatics studies have… CONTINUE READING