Endogenous retinoid X receptors can function as hormone receptors in pituitary cells.

@article{Davis1994EndogenousRX,
  title={Endogenous retinoid X receptors can function as hormone receptors in pituitary cells.},
  author={Kent Davis and Tom J Berrodin and John E Stelmach and James D. Winkler and Mitchell A Lazar},
  journal={Molecular and cellular biology},
  year={1994},
  volume={14 11},
  pages={7105-10}
}
Retinoids regulate gene transcription by interacting with both retinoic acid (RA) receptors (RARs) and retinoid X receptors (RXRs). Since unliganded RXRs can act as heterodimerization partners for RARs and other nuclear hormone receptors, it is unclear whether ligand binding by RXRs actually regulates the expression of naturally occurring genes. To address this issue, we synthesized the RXR-selective retinoid SR11237 and confirmed its specificity in transient transfection and proteolytic… CONTINUE READING

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