Endogenous regulatory T cells adhere in inflamed dermal vessels via ICAM-1: association with regulation of effector leukocyte adhesion.

@article{Deane2012EndogenousRT,
  title={Endogenous regulatory T cells adhere in inflamed dermal vessels via ICAM-1: association with regulation of effector leukocyte adhesion.},
  author={James A Deane and Latasha D. Abeynaike and M. Ursula Norman and Janet L. Wee and Arthur Richard Kitching and Paul Kubes and Michael J Hickey},
  journal={Journal of immunology},
  year={2012},
  volume={188 5},
  pages={2179-88}
}
Regulatory T cells (Tregs) must express appropriate skin-homing adhesion molecules to exert suppressive effects on dermal inflammation. However, the mechanisms whereby they control local inflammation remain unclear. In this study we used confocal intravital microscopy in wild-type and Foxp3-GFP mice to examine adhesion of effector T cells and Tregs in dermal venules. These experiments examined a two-challenge model of contact sensitivity (CS) in which Treg abundance in the skin progressively… CONTINUE READING
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