Endogenous reductions in N-methyl-d-aspartate receptor activity inhibit nitric oxide production in the anoxic freshwater turtle cortex.

Abstract

Increased nitric oxide (NO) production from hypoxic mammalian neurons increases cerebral blood flow (CBF) but also glutamatergic excitotoxicity and DNA fragmentation. Anoxia-tolerant freshwater turtles have evolved NO-independent mechanisms to increase CBF; however, the mechanism(s) of NO regulation are not understood. In turtle cortex, anoxia or NMDAR… (More)
DOI: 10.1016/j.febslet.2008.04.041

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Cite this paper

@article{Pamenter2008EndogenousRI, title={Endogenous reductions in N-methyl-d-aspartate receptor activity inhibit nitric oxide production in the anoxic freshwater turtle cortex.}, author={Matthew Edward Pamenter and David W. Hogg and Leslie T Buck}, journal={FEBS letters}, year={2008}, volume={582 12}, pages={1738-42} }