Endogenous pyrogen activity in human plasma after exercise.

@article{Cannon1983EndogenousPA,
  title={Endogenous pyrogen activity in human plasma after exercise.},
  author={Joseph G. Cannon and Matthew Jay Kluger},
  journal={Science},
  year={1983},
  volume={220 4597},
  pages={617-9}
}
Plasma obtained from human subjects after exercise and injected intraperitoneally into rats elevated rat rectal temperature and depressed plasma iron and zinc concentrations. The pyrogenic component was heat-denaturable and had an apparent molecular weight of 14,000 daltons. Human mononuclear leukocytes obtained after exercise and incubated in vitro released a factor into the medium that also elevated body temperature in rats and reduced trace metal concentrations. These results suggest that… CONTINUE READING

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