Endogenous proteolytic cleavage of disease-associated prion protein to produce C2 fragments is strongly cell- and tissue-dependent.

@article{Dron2010EndogenousPC,
  title={Endogenous proteolytic cleavage of disease-associated prion protein to produce C2 fragments is strongly cell- and tissue-dependent.},
  author={Michel Dron and Mohammed Moudjou and J{\'e}r{\^o}me Chapuis and Muhammad Khalid Farooq Salamat and Julie L. Bernard and Sabrina Cronier and Christelle Langevin and Hubert Laude},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 14},
  pages={10252-64}
}
The abnormally folded form of the prion protein (PrP(Sc)) accumulating in nervous and lymphoid tissues of prion-infected individuals can be naturally cleaved to generate a N-terminal-truncated fragment called C2. Information about the identity of the cellular proteases involved in this process and its possible role in prion biology has remained limited and controversial. We investigated PrP(Sc) N-terminal trimming in different cell lines and primary cultured nerve cells, and in the brain and… CONTINUE READING

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