Endogenous proteins controlling amyloid beta-peptide polymerization. Possible implications for beta-amyloid formation in the central nervous system and in peripheral tissues.

@article{Bohrmann1999EndogenousPC,
  title={Endogenous proteins controlling amyloid beta-peptide polymerization. Possible implications for beta-amyloid formation in the central nervous system and in peripheral tissues.},
  author={Bernd Bohrmann and Lars O. Tjernberg and Prof. Dr. med E. H. Kuner and Sonia Maria Poli and Bernard Levet-Trafit and Jan E N{\"a}slund and Grayson J. Richards and W. Huber and Heinz Doebeli and C K Nordstedt},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 23},
  pages={
          15990-5
        }
}
We report that certain plasma proteins, at physiological concentrations, are potent inhibitors of amyloid beta-peptide (Abeta) polymerization. These proteins are also present in cerebrospinal fluid, but at low concentrations having little or no effect on Abeta. Thirteen proteins representing more than 90% of the protein content in plasma and cerebrospinal fluid were studied. Quantitatively, albumin was the most important protein, representing 60% of the total amyloid inhibitory activity… CONTINUE READING
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