Endogenous protein C is essential for the functional integrity of human endothelial cells

@article{Xue2010EndogenousPC,
  title={Endogenous protein C is essential for the functional integrity of human endothelial cells},
  author={Meilang Xue and Nikita Minhas and Shu-Oi Chow and Suat Dervish and Philip N. Sambrook and Lyn March and Christopher J. Jackson},
  journal={Cellular and Molecular Life Sciences},
  year={2010},
  volume={67},
  pages={1537-1546}
}
Circulating protein C (PC) plays a vital role as an anti-coagulant and anti-inflammatory mediator. We show here that human endothelial cells produce PC that acts through novel mediators to enhance their own functional integrity. When endogenous PC or its receptor, endothelial protein C receptor (EPCR), was suppressed by small interfering (si) RNA, human umbilical cord endothelial cell (HUVEC) proliferation was decreased and apoptosis elevated. Interestingly, PC or EPCR siRNA significantly… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-9 OF 9 CITATIONS

Activated Protein C in Cutaneous Wound Healing: From Bench to Bedside

  • International journal of molecular sciences
  • 2019
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Fatal cerebral malaria: a venous efflux problem

  • Front. Cell. Infect. Microbiol.
  • 2014
VIEW 5 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 47 REFERENCES

Activated protein C utilizes the angiopoietin/Tie2 axis to promote endothelial barrier function.

  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2010
VIEW 2 EXCERPTS

Activated protein C--an anticoagulant that does more than stop clots.

  • The international journal of biochemistry & cell biology
  • 2008
VIEW 1 EXCERPT

Similar Papers