Endogenous prostaglandin E2 mediates inhibition of rat thick ascending limb Cl reabsorption in chronic hypercalcemia.

@article{Peterson1993EndogenousPE,
  title={Endogenous prostaglandin E2 mediates inhibition of rat thick ascending limb Cl reabsorption in chronic hypercalcemia.},
  author={Linda N Peterson and A J McKay and J S Borzecki},
  journal={The Journal of clinical investigation},
  year={1993},
  volume={91 6},
  pages={2399-407}
}
The hypothesis that endogenous PGE2 mediates defective thick ascending limb (TAL) Cl reabsorption (percent delivered load: FRCl%) in rats with vitamin D-induced chronic hypercalcemia (HC) was tested by measuring FRCl% in loop segments microperfused in vivo in HC and control rats treated acutely with indomethacin (Indo) or its vehicle, and obtaining the corresponding outer medullary [PGE2]. Microperfusion conditions were developed in which FRCl% was exclusively furosemide sensitive. To determine… CONTINUE READING

From This Paper

Figures and tables from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 28 references

Effect of cytochrome P 450 arachidonate metabolites on ion transport in rabbit loop of Henle

  • L. Gil, M. Orellana, L. J. Marnett, J. I. Mason, P. Yadagiri
  • Science ( Wash . DC ) .
  • 1991

Vasopres - sin alters the mechanism of apical Cl - entry from Na + : CIP to Na + : K + : 2 Cl 1 cotransport in mouse medullary thick ascending limb

  • D. Kaji
  • J . Membr . Biol .
  • 1991

Effective indomethacin in vivo and PGE 2 in vitro on MTALNa - K - ATPase of the rat kidney

  • W. B. Campbell, T. D. DuBose
  • Pfluegers Arch . Eur . J . Physiol .
  • 1990

Similar Papers

Loading similar papers…